34_Deuterostomia Link Wikipedia to Phmamm Link Ensembl
×2 ÷2 Center the view on the reference gene Shift 1 gene on the left Shift 5 genes on the left Shift 1 gene on the right Shift 5 genes on the right Zoom out Show 1 less gene on each side Show 1 more gene on each side Show half the number of genes on each side Show twice more genes on each side Zoom in
Schematic scale
Genomic scale

dN/dS Ratio
Protein Similarity
CNE Track
34_Deuterostomia speciation node (click to collapse) 34_Deuterostomia (~10 My ago) - block_587 Fam002107.C Click to hide this line (30_Chordata) 30_Chordata speciation node (click to collapse) 30_Chordata (~10 My ago) - block_477 Fam002107.C Click to hide this line (28) 28 speciation node (click to collapse) 28 (~10 My ago) Click to hide this line (16_Ascidiacea) 16_Ascidiacea speciation node (click to collapse) 16_Ascidiacea (~10 My ago) Click to hide this line (15_Phlebobranchia) 15_Phlebobranchia speciation node (click to collapse) 15_Phlebobranchia (~10 My ago) Click to show this node (14_Phallusia) 14_Phallusia speciation node (click to collapse) Click to hide this line (Phmamm) Phmamm terminal node Phmamm - Chr:S270 Click to hide this line (11_Ciona) 11_Ciona speciation node (click to collapse) 11_Ciona (~10 My ago) Click to hide this line (Cirobu) Cirobu terminal node Cirobu - Chr:KhC5 KH2012:KH.C5.387 KH2012:KH.C5.18 KH2012:KH.C5.273 KH2012:KH.C5.605 KH2012:KH.C5.123 KH2012:KH.C5.390 KH2012:KH.C5.134 KH2012:KH.C5.9 KH2012:KH.C5.206 KH2012:KH.C5.622 KH2012:KH.C5.333 KH2012:KH.C5.62 KH2012:KH.C5.532 KH2012:KH.C5.447 KH2012:KH.C5.412 KH2012:KH.C5.409 KH2012:KH.C5.629 KH2012:KH.C5.249 KH2012:KH.C5.573 KH2012:KH.C5.28 KH2012:KH.C5.652 KH2012:KH.C5.529 KH2012:KH.C5.439 KH2012:KH.C5.176 KH2012:KH.C5.478 KH2012:KH.C5.313 KH2012:KH.C5.366 KH2012:KH.C5.545 KH2012:KH.C5.650 KH2012:KH.C5.11 Click to hide this line (Cisavi) Cisavi terminal node Cisavi - Chr:reftig_60 Cisavi.CG.ENS81.R60.608319-610524 (ENSCSAVG00000006515) Cisavi.CG.ENS81.R60.627164-657930 (ENSCSAVG00000006518) Cisavi.CG.ENS81.R60.674897-791456 (ENSCSAVG00000006778) Cisavi.CG.ENS81.R60.791511-799594 (ENSCSAVG00000006917) Cisavi.CG.ENS81.R60.801899-815746 (ENSCSAVG00000006927) Cisavi.CG.ENS81.R60.817138-821813 (ENSCSAVG00000007022) Cisavi.CG.ENS81.R60.822386-826629 (ENSCSAVG00000007025) Cisavi.CG.ENS81.R60.829206-832424 (ENSCSAVG00000007027) Cisavi.CG.ENS81.R60.834213-837976 (ENSCSAVG00000007030) Cisavi.CG.ENS81.R60.877433-878725 (ENSCSAVG00000007031) Cisavi.CG.ENS81.R60.909488-914023 (ENSCSAVG00000007033) Cisavi.CG.ENS81.R60.913647-924837 (ENSCSAVG00000007039) Cisavi.CG.ENS81.R60.936911-947184 (ENSCSAVG00000007534) Cisavi.CG.ENS81.R60.948212-959484 (ENSCSAVG00000007546) Cisavi.CG.ENS81.R60.987391-989533 (ENSCSAVG00000007659) Cisavi.CG.ENS81.R60.1007042-1009306 (ENSCSAVG00000007666) Cisavi.CG.ENS81.R60.1018153-1020426 (ENSCSAVG00000007680) Cisavi.CG.ENS81.R60.1076144-1081115 (ENSCSAVG00000007693) Cisavi.CG.ENS81.R60.1083737-1089461 (ENSCSAVG00000007697) Cisavi.CG.ENS81.R60.1103357-1104131 (ENSCSAVG00000007725) Cisavi.CG.ENS81.R60.1109413-1112403 (ENSCSAVG00000007726) Cisavi.CG.ENS81.R60.1115884-1119201 (ENSCSAVG00000007728) Cisavi.CG.ENS81.R60.1120943-1122012 (ENSCSAVG00000007731) Cisavi.CG.ENS81.R60.1137678-1143325 (ENSCSAVG00000007744) Cisavi.CG.ENS81.R60.1150282-1162980 (ENSCSAVG00000007752) Cisavi.CG.ENS81.R60.1163847-1165577 (ENSCSAVG00000007899) Click to hide this line (8_Stolidobranchia) 8_Stolidobranchia speciation node (click to collapse) 8_Stolidobranchia (~10 My ago) Click to hide this line (2_Molgula) 2_Molgula speciation node (click to collapse) 2_Molgula (~10 My ago) Click to hide this line (Moocci) Moocci terminal node Moocci - Chr:S621144 Moocci.CG.ELv1_2.S621144.g26405 Moocci.CG.ELv1_2.S621144.g26406 Moocci.CG.ELv1_2.S621144.g26408 Moocci.CG.ELv1_2.S621144.g26409 Moocci.CG.ELv1_2.S621144.g26410 Moocci.CG.ELv1_2.S621144.g26411 Click to hide this line (Moocul) Moocul terminal node Moocul - Chr:S59533 Moocul.CG.ELv1_2.S59533.g03728 Moocul.CG.ELv1_2.S59533.g03729 Moocul.CG.ELv1_2.S59533.g03730 Moocul.CG.ELv1_2.S59533.g03731 Moocul.CG.ELv1_2.S59533.g03732 Moocul.CG.ELv1_2.S59533.g03734 Click to hide this line (7) 7 speciation node (click to collapse) 7 (~10 My ago) Click to hide this line (Boschl) Boschl terminal node Boschl - Chr:chr6 Boschl.CG.Botznik2013.chr6.g68578 Boschl.CG.Botznik2013.chr6.g68579 Boschl.CG.Botznik2013.chr6.g68623 Boschl.CG.Botznik2013.chr6.g68661 Boschl.CG.Botznik2013.chr6.g68759 Boschl.CG.Botznik2013.chr6.g68967 Boschl.CG.Botznik2013.chr6.g68977 Boschl.CG.Botznik2013.chr6.g68978 Boschl.CG.Botznik2013.chr6.g69077 Boschl.CG.Botznik2013.chr6.g69153 Boschl.CG.Botznik2013.chr6.g69154 Boschl.CG.Botznik2013.chr6.g69158 Boschl.CG.Botznik2013.chr6.g69159 Boschl.CG.Botznik2013.chr6.g66604 Boschl.CG.Botznik2013.chr6.g65892 Boschl.CG.Botznik2013.chr6.g64432 Boschl.CG.Botznik2013.chr6.g64433 Boschl.CG.Botznik2013.chr6.g64434 Boschl.CG.Botznik2013.chr6.g64495 Boschl.CG.Botznik2013.chr6.g64496 Boschl.CG.Botznik2013.chr6.g64509 Boschl.CG.Botznik2013.chr6.g64522 Boschl.CG.Botznik2013.chr6.g64523 Boschl.CG.Botznik2013.chr6.g64524 Boschl.CG.Botznik2013.chr6.g64568 Boschl.CG.Botznik2013.chr6.g64571 Boschl.CG.Botznik2013.chr6.g64572 Boschl.CG.Botznik2013.chr6.g63855 Boschl.CG.Botznik2013.chr6.g63856 Boschl.CG.Botznik2013.chr6.g64891 Click to show this node (6_Halocynthia) 6_Halocynthia speciation node (click to collapse) Click to hide this line (Harore) Harore terminal node Harore - Chr:S135 Harore.CG.MTP2014.S135.g12806 Harore.CG.MTP2014.S135.g15945 Harore.CG.MTP2014.S135.g06767 Harore.CG.MTP2014.S135.g09080 Harore.CG.MTP2014.S135.g14411 Harore.CG.MTP2014.S135.g01442 Harore.CG.MTP2014.S135.g13477 Harore.CG.MTP2014.S135.g14399 Harore.CG.MTP2014.S135.g13691 Harore.CG.MTP2014.S135.g14540 Harore.CG.MTP2014.S135.g06442 Harore.CG.MTP2014.S135.g15987 Harore.CG.MTP2014.S135.g15221 Harore.CG.MTP2014.S135.g10885 Harore.CG.MTP2014.S135.g05390 Click to show this node (26_Sarcopterygii) 26_Sarcopterygii duplication node (click to collapse) Click to hide this line (26_Sarcopterygii) 26_Sarcopterygii speciation node (click to collapse) 26_Sarcopterygii (~10 My ago) Click to hide this line (25_Amniota) 25_Amniota speciation node (click to collapse) 25_Amniota (~10 My ago) - block_68 Fam002374.E.a.a Fam004668.a Fam002224.C.b Fam001779.R.a.a Fam004283.b.a.b Fam006696.b.a Fam006425 Fam001671.B.b.a Fam001899.C.a.b.b Fam002679.F.a Fam007534.b Fam005384.a.b.a Fam001878.K.a.a Fam001797.G Fam002704.B.c.b Click to hide this line (24_Euarchontoglires) 24_Euarchontoglires speciation node (click to collapse) 24_Euarchontoglires (~10 My ago) - block_49 Fam006425 Fam003727.a.a Fam002571.B.a.a Fam004289.A.b Fam005543.B.b.a Fam001671.B.b.a Fam001899.C.a.b.b Fam004744.a.a.b Fam002679.F.b Fam007534.b Fam005384.a.b.a Fam001878.K.a.a Fam001797.G Fam002704.B.c.b Fam007516.b.a.a Fam001881.A Fam002379.B.b.a.b Fam001812.K.a.b.a.b Fam001944.F.a Fam001420.b.a.b.b Fam001747.H.b.a Fam001747.H.b.b Fam002380.F.b Fam005673.b Fam011024.b.a.b Fam001706.F.d Fam004632.A Fam007123.a Fam003668.b Fam007459 Click to hide this line (Mmus) Mmus terminal node Mmus - Chr:13 ENSMUSG00000012422 ENSMUSG00000094277 ENSMUSG00000078958 ENSMUSG00000049517 ENSMUSG00000021619 ENSMUSG00000003992 ENSMUSG00000021620 ENSMUSG00000021621 ENSMUSG00000021622 ENSMUSG00000021708 ENSMUSG00000100622 ENSMUSG00000014850 ENSMUSG00000021707 ENSMUSG00000045034 ENSMUSG00000034334 ENSMUSG00000046957 ENSMUSG00000021703 ENSMUSG00000021702 ENSMUSG00000021704 ENSMUSG00000047419 ENSMUSG00000042167 ENSMUSG00000007617 ENSMUSG00000021690 ENSMUSG00000074768 ENSMUSG00000042118 ENSMUSG00000042102 ENSMUSG00000042082 ENSMUSG00000045312 ENSMUSG00000021687 ENSMUSG00000042857 Click to hide this line (Hsap) Hsap terminal node Hsap - Chr:5 ENSG00000132842 ENSG00000085365 ENSG00000145685 ENSG00000113273 ENSG00000132837 ENSG00000132840 ENSG00000145692 ENSG00000152409 ENSG00000152413 ENSG00000164329 ENSG00000164309 ENSG00000177034 ENSG00000113296 ENSG00000164300 ENSG00000164299 ENSG00000152380 ENSG00000189127 ENSG00000228716 ENSG00000113318 ENSG00000113319 ENSG00000131730 ENSG00000131732 ENSG00000172497 ENSG00000145687 ENSG00000152348 ENSG00000186468 ENSG00000205464 ENSG00000174695 ENSG00000152422 ENSG00000038427 Click to hide this line (21_Archelosauria) 21_Archelosauria speciation node (click to collapse) 21_Archelosauria (~10 My ago) - block_71 Fam002197.a.b Fam009602.a.a Fam002704.B.c.b Fam001797.G Fam001878.K.a.a Fam005384.a.b.a Fam007534.b Fam002679.F.a Fam001899.C.a.b.a Fam001671.B.b.a Fam004289.A.b Fam002571.B.a.a Fam006425 Fam006696.b.a Fam004283.b.a.b Fam001779.R.a.a Fam002224.C.b Click to hide this line (Ggal) Ggal terminal node Ggal - Chr:Z ENSGALG00000015624 ENSGALG00000015620 ENSGALG00000027332 ENSGALG00000015618 ENSGALG00000015617 ENSGALG00000027714 ENSGALG00000023089 ENSGALG00000015616 ENSGALG00000015603 ENSGALG00000015602 ENSGALG00000015598 ENSGALG00000015589 ENSGALG00000026757 ENSGALG00000015578 ENSGALG00000015577 ENSGALG00000015572 ENSGALG00000020534 ENSGALG00000015571 ENSGALG00000026461 ENSGALG00000026946 ENSGALG00000015555 ENSGALG00000015551 ENSGALG00000015548 ENSGALG00000015545 ENSGALG00000015544 ENSGALG00000015543 ENSGALG00000015542 ENSGALG00000028000 ENSGALG00000026954 ENSGALG00000028441 Click to hide this line (Psin) Psin terminal node Psin - Chr:JH209116.1 ENSPSIG00000014530 ENSPSIG00000014559 ENSPSIG00000014565 ENSPSIG00000014628 ENSPSIG00000014648 ENSPSIG00000014742 ENSPSIG00000014765 ENSPSIG00000014777 ENSPSIG00000014787 ENSPSIG00000014792 ENSPSIG00000014805 ENSPSIG00000014945 ENSPSIG00000015082 ENSPSIG00000015089 ENSPSIG00000000799 ENSPSIG00000000806 ENSPSIG00000015226 ENSPSIG00000015278 ENSPSIG00000015542 ENSPSIG00000015555 ENSPSIG00000015748 ENSPSIG00000015854 ENSPSIG00000015897 ENSPSIG00000015983 ENSPSIG00000015998 ENSPSIG00000016006 ENSPSIG00000016011 ENSPSIG00000016026 ENSPSIG00000016032 ENSPSIG00000016043 Click to hide this line (Lcha) Lcha terminal node Lcha - Chr:JH127607.1 ENSLACG00000003521 ENSLACG00000006850 ENSLACG00000008005 ENSLACG00000008431 ENSLACG00000009936 ENSLACG00000010493 ENSLACG00000010787 ENSLACG00000010985 ENSLACG00000011457 ENSLACG00000011940 ENSLACG00000012444 Click to hide this line (26_Sarcopterygii) 26_Sarcopterygii speciation node (click to collapse) 26_Sarcopterygii (~10 My ago) - block_354 Fam002611.A Fam001810.F Fam002925.B.b Click to hide this line (Lcha) Lcha terminal node Lcha - Chr:JH127685.1 ENSLACG00000001406 ENSLACG00000005911 ENSLACG00000010254 ENSLACG00000010525 ENSLACG00000011982 Click to hide this line (25_Amniota) 25_Amniota speciation node (click to collapse) 25_Amniota (~10 My ago) - block_8 Fam004747.a.b Fam007453.b Fam001852.B.b Fam002472.L Fam004751.a.a.b Fam002324.K.d.b.b Fam003886.c.a Fam006103 Fam006507.A.a.b Fam007027.b.b.b Fam006461.a.a Fam002611.A Fam001810.F Fam002925.B.b.a Fam001855.F Fam001855.C Fam002471.G.b.b Fam006628.A.a.a Fam007638.b Fam001778.D.a.a.a Fam006934.b Fam003148.B Fam006639.A.a.a Fam003710 Fam002013.D.b Fam004929.b Fam004759.b.b Fam002694.E Fam009090.a.a Click to hide this line (21_Archelosauria) 21_Archelosauria speciation node (click to collapse) 21_Archelosauria (~10 My ago) - block_5 Fam004929.b Fam002013.D.b Fam003710 Fam006639.A.a.a Fam003148.B Fam006934.b Fam001778.D.a.a.a Fam007638.b Fam006628.A.a.a Fam002471.G.b.b Fam004006.A.b Fam002323.K.a.b.a Fam002741.B.a.b Fam001855.C Fam001855.F Fam002925.B.b.b Fam001810.F.b Fam002611.A Fam006461.a.a Fam007027.b.b.b Fam006507.A.a.b Fam006103 Fam003886.c.a Fam002324.K.d.b.b Fam004751.a.a.b Fam002472.L Fam001852.B.b Fam007453.b Fam002388.D.c.a.a.a Click to hide this line (Ggal) Ggal terminal node Ggal - Chr:8 ENSGALG00000010494 ENSGALG00000010502 ENSGALG00000010505 ENSGALG00000010533 ENSGALG00000028493 ENSGALG00000010536 ENSGALG00000010537 ENSGALG00000010539 ENSGALG00000010540 ENSGALG00000010543 ENSGALG00000010555 ENSGALG00000010565 ENSGALG00000010569 ENSGALG00000010570 ENSGALG00000010619 ENSGALG00000010623 ENSGALG00000010627 ENSGALG00000010629 ENSGALG00000010633 ENSGALG00000028647 ENSGALG00000016099 ENSGALG00000010637 ENSGALG00000010643 ENSGALG00000010647 ENSGALG00000010652 ENSGALG00000021869 ENSGALG00000010673 ENSGALG00000010681 ENSGALG00000026516 Click to hide this line (Psin) Psin terminal node Psin - Chr:JH209559.1 ENSPSIG00000005771 ENSPSIG00000006011 ENSPSIG00000006478 ENSPSIG00000008562 ENSPSIG00000009575 ENSPSIG00000010062 ENSPSIG00000012053 ENSPSIG00000013513 ENSPSIG00000016054 ENSPSIG00000016090 ENSPSIG00000016322 ENSPSIG00000016704 ENSPSIG00000017487 ENSPSIG00000005729 ENSPSIG00000007609 ENSPSIG00000009183 ENSPSIG00000000608 ENSPSIG00000009351 ENSPSIG00000009906 ENSPSIG00000014233 ENSPSIG00000015754 ENSPSIG00000017765 ENSPSIG00000006280 ENSPSIG00000006283 ENSPSIG00000006306 ENSPSIG00000008525 ENSPSIG00000008545 ENSPSIG00000000289 ENSPSIG00000008975 Click to hide this line (24_Euarchontoglires) 24_Euarchontoglires speciation node (click to collapse) 24_Euarchontoglires (~10 My ago) - block_2 Fam001777.H.b.a Fam006639.A.a.a Fam003148.B Fam006934.b Fam001778.D.a.a.a Fam007638.b Fam006628.A.a.a Fam002471.G.b.b Fam002099.E.c Fam002099.E.d.b Fam004006.A.b Fam002323.K.a.b.a Fam002741.B.a.b Fam001855.C Fam001855.F Fam002925.B.b.a Fam006646.A.b Fam003887.A.a Fam001810.F Fam002611.A Fam006461.a.a Fam007027.b.b.b Fam006507.A.a.b Fam006103 Fam001777.F.a.a Fam006055.A.b.b.b.a.a Fam001725.E Fam003886.c.a Fam002324.K.d.b.b Click to hide this line (Hsap) Hsap terminal node Hsap - Chr:1 ENSG00000162373 ENSG00000162374 ENSG00000142700 ENSG00000185104 ENSG00000123080 ENSG00000204006 ENSG00000123091 ENSG00000085831 ENSG00000085832 ENSG00000117859 ENSG00000078618 ENSG00000198841 ENSG00000117862 ENSG00000134717 ENSG00000154222 ENSG00000085840 ENSG00000134748 ENSG00000134744 ENSG00000116157 ENSG00000182183 ENSG00000162377 ENSG00000162378 ENSG00000203995 ENSG00000121310 ENSG00000116171 ENSG00000279054 ENSG00000174348 ENSG00000162383 ENSG00000157184 Click to hide this line (Mmus) Mmus terminal node Mmus - Chr:4 ENSMUSG00000028608 ENSMUSG00000028607 ENSMUSG00000008932 ENSMUSG00000028600 ENSMUSG00000028603 ENSMUSG00000028601 ENSMUSG00000034645 ENSMUSG00000034636 ENSMUSG00000048351 ENSMUSG00000059816 ENSMUSG00000028597 ENSMUSG00000034610 ENSMUSG00000063800 ENSMUSG00000028587 ENSMUSG00000028582 ENSMUSG00000094958 ENSMUSG00000028568 ENSMUSG00000028567 ENSMUSG00000090551 ENSMUSG00000073775 ENSMUSG00000053510 ENSMUSG00000028559 ENSMUSG00000028558 ENSMUSG00000028552 ENSMUSG00000028555 ENSMUSG00000028557 ENSMUSG00000060491 ENSMUSG00000028551 ENSMUSG00000010517 Click to hide this line (Bbel) Bbel terminal node Bbel - scaffold33 165700F 165710F 165720R 165730R 165740F 165750R 165760R 165770R 165780F 165790F 165800F 165810R 165820F 165830R 165840F 165860R 165870F 165880R 165890F 165900R 165910F 165920R 165930F 165940R 165950R 165960R 165970F 165980F 165990R 166000F Click to hide this line (33) 33 speciation node (click to collapse) 33 (~10 My ago) - block_240 Fam002107.C Click to hide this line (Spur) Spur terminal node Spur - Chr:Scaffold1546 SPU_007838 SPU_014775 SPU_014774 SPU_014776 SPU_009561 SPU_020957 SPU_026663 SPU_014772 SPU_014769 SPU_008731 SPU_014777 SPU_014764 SPU_011142 SPU_014778 SPU_014762 SPU_026932 Click to hide this line (Skow) Skow terminal node Skow - scaffold_718 Sakowv30020454m.g Sakowv30020476m.g Sakowv30020474m.g Sakowv30020456m.g Sakowv30020452m.g Sakowv30020465m.g Sakowv30020464m.g Sakowv30020469m.g Sakowv30020477m.g Sakowv30020467m.g Sakowv30020462m.g Sakowv30020461m.g Sakowv30020459m.g Sakowv30020468m.g Sakowv30020458m.g Sakowv30020475m.g Sakowv30020450m.g Sakowv30020470m.g Sakowv30020463m.g Sakowv30020466m.g Sakowv30020457m.g Sakowv30020473m.g Sakowv30020471m.g Phmamm.CG.MTP2014.S270.g06447 Phmamm.CG.MTP2014.S270.g06444 Phmamm.CG.MTP2014.S270.g06460 Phmamm.CG.MTP2014.S270.g06446 Harore.CG.MTP2014.S135.g06476 Phmamm.CG.MTP2014.S270.g06457 Phmamm.CG.MTP2014.S270.g06454 Phmamm.CG.MTP2014.S270.g06459 Phmamm.CG.MTP2014.S270.g06456 Phmamm.CG.MTP2014.S270.g06451 Phmamm.CG.MTP2014.S270.g06463 Phmamm.CG.MTP2014.S270.g06450 Phmamm.CG.MTP2014.S270.g06453 Phmamm.CG.MTP2014.S270.g06455 Phmamm.CG.MTP2014.S270.g06461 Phmamm.CG.MTP2014.S270.g06449 Phmamm.CG.MTP2014.S270.g06443 Cisavi.CG.ENS81.R60.660220-666782 (ENSCSAVG00000006710) Fam002336.SH.a Fam002336.SH.a ENSGALG00000010567 Fam002336.SH.a ENSG00000169213 ENSMUSG00000003411 Fam003697 Fam003697 Fam003697 Fam003697 Fam003697 Phmamm.CG.MTP2014.S270.g06448 Fam003697 KH2012:KH.C5.365 Cisavi.CG.ENS81.R60.962489-971916 (ENSCSAVG00000007648) Fam003697 Fam003697 Moocci.CG.ELv1_2.S621144.g26407 Moocul.CG.ELv1_2.S59533.g03733 Fam003697 Boschl.CG.Botznik2013.chr6.g64332 Harore.CG.MTP2014.S135.g05227 Fam003697.a Fam003697.a Fam003697.a ENSMUSG00000021706 ENSG00000039319 Fam003697.a ENSGALG00000015576 ENSPSIG00000015107 ENSLACG00000009040 Fam003697.b ENSLACG00000011209 Fam003697.b Fam003697.b ENSGALG00000010613 ENSPSIG00000006343 Fam003697.b ENSG00000157077 ENSMUSG00000034557 165850R Fam003697 SPU_014763 Sakowv30020446m.g Phmamm.CG.MTP2014.S270.g06462 Phmamm.CG.MTP2014.S270.g06458 Phmamm.CG.MTP2014.S270.g06452 Phmamm.CG.MTP2014.S270.g06445